Dr. Claudio A. Sáez

LACER Postdoctoral Researcher  

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1.- Studies

2015. Postdoctoral Fellow, Laboratory of Marine Biotechnology, Universidad de Santiago de Chile.

2014. Doctor of Philosophy (PhD) Marine Studies. School of Marine Science & Engineering, Plymouth University, United Kingdom.

2012. Diploma in Learning and Teaching in Higher Education, Plymouth University, United Kingdom.

2010. Environmental Engineer. Universidad de Valparaíso, Chile; Victoria University of Wellington, New Zealand (2007-2008).

2010. Bachelor in Environmental Engineering. Universidad de Valparaíso, Chile; Victoria University of Wellington, New Zealand (2007-2008).

2.- Research areas

- Marine ecotoxicology

- Biomonitoring

- Stress metabolism

- Transcriptomics

- Phycology

My field of study is related to the effects of pollutants and environmental perturbations on the biology of organisms, especially primary producers at marine ecosystems. My research is focused mainly in macroalgae, and their responses to metal excess or stressors associated with Climate Change, in temperate and polar ecosystems. I study stress responses at different levels of biological organization, from metabolism at molecular and biochemical levels, to effects on the physiology and population and community structures. We also evaluate molecular and biochemical stress signals as potential biomarkers, which can be applied as biotechnology tools for the prediction, diagnosis and monitoring of environmental status.

3.- Articles 

Gómez M, González A, Moenne F, Sáez CA, Moenne A (2017) Copper-induced early responses involve the activation of Transient Receptor Potential (TRP) channels, release of amino acids, serotonin and adrenalin, and activation of homologs of glutamate, adrenalin and serotonin receptors in the marine alga Ulva compressa. Algal Research 26: 115-122.

- Valdés F, Díaz P, Lobos MG, Sáez CA (2017) Metal assessment and cellular accumulation dynamics in the green macroalga Ulva lactucaJournal of Applied Phycology. In press. DOI: 10.1007/s10811-017-1244-x

- Laporte, D., Valdés, N., González, A., Sáez, C.A., Zúñiga, A., Navarrete, A., Meneses, C., Moenne, A. (2016) Copper-induced overexpression of genes encoding antioxidant system enzymes and metallothioneins involve the activation of CaMs, CDPKs and MEK1/2 in the marine alga Ulva compressaAquatic Toxicology 177, 433-440 (WoS - IF: 3.6).

- Gómez, M., González, A., Sáez, C.A., Moenne, A. (2016) Copper-induced membrane depolarizations involve the induction of mosaic TRP channels, which activate VDCC leading to calcium increases in Ulva compressa. Frontiers in Plant Science 7, 754 (WoS - IF: 4.5)

- Moenne, A., González, A., Sáez, C. A. (2016) Mechanisms of metal tolerance in marine macroalgae, with emphasis on copper tolerance in Chlorophyta and Rhodophyta. Aquatic Toxicology 176, 30-37 (WoS - IF: 3.6).

- Moya, M. G., Vega-Román, E., Sáez, C. A., Mundaca, E. A. (2015) Extension of the distributional range of Lithobius obscurus Meinert (Lithobiidae, Lithobiomorpha) in organic and conventional apple orchards in Central Chile. Gayana 79, 217-219 (WoS - IF: 0.3).

Sáez, C.A.*, Ramesh, K.*, Greco, M., Bitonti, M. B., Brown, M. T. (2015) Enzymatic antioxidant defences are transcriptionally regulated in Es524, a copper-tolerant strain of Ectocarpus siliculosus (Ectocarpales; Phaeophyceae). Phycologia 54, 425-429 (WoS - IF: 1.6).

Sáez, C.A., González, A., Contreras, R., Moody, J., Moenne, A., Brown, M.T. (2015) A novel field transplantation technique reveals intra-specific metal-induced oxidative responses in strains of Ectocarpus siliculosus with different pollution histories. Environmental Pollution (2015) 199, 130-138 (WoS - IF: 4.8).

Sáez, C.A.*, Roncarati, F.*,Moenne, A., Moody, A. J., Brown, M. T. (2015) Copper-induced intra-specific oxidative damage and antioxidant responses in strains of the brown alga Ectocarpus siliculosus with different pollution histories. Aquatic Toxicology 159, 81-89 (WoS - IF: 3.6).

- Gómez, M., González, A., Sáez, C.A., Morales, B., Moenne, A. (2015) Copper-induced activation of TRP channels promotes extracellular calcium entry and activation of CaMs and CDPKs leading to copper entry and membrane depolarization in Ulva compressa. Frontiers in Plant Science 6, 182 (WoS - IF: 4.5).

Sáez, C.A.*, Roncarati, F.*, Greco, M., Gledhill, M, Bitonti, B, Brown, M.T. (2015) Response differences between Ectocarpus siliculosus populations to copper stressinvolve cellular exclusion and induction of the phytochelatin biosynthetic pathway. Aquatic Toxicology 159, 167-175 (WoS - IF: 3.6).

- González, A., Moenne, F., Contreras, R. A., Gómez, M., Sáez, C.A., Moenne, A. (2014) Oligo-carrageenan kappa increases NADPH, ascorbate and glutathione syntheses and TRR/TRX activities enhancing photosynthesis, basal metabolism, and growth in Eucalyptus trees. Frontiers in Plant Science 5, 512 (WoS - IF: 4.5).

- Greco, M., Sáez, C. A., Brown, M. T., Bitonti, M. B. (2014) A simple and effective method for high quality co-extraction of genomic DNA and total RNA from low biomass Ectocarpus siliculosus, the model brown alga. PLoS ONE 9, e96470 (WoS - IF: 3.1).

- Ortega, K. J., Sáez, C.A., Macaya, E. (2014) Changes in invertebrate communities inhabiting Lessonia spicata (Phaeophyceae) holdfasts after the 2010 earthquake-mediated coastal uplift in Chile. Revista de Biologia Marina y Oceanografia 49, 129-134 (WoS - IF: 0.5).

Sáez, C.A., Pérez-Matus, A., Lobos, M.G., Oliva, D., Vásquez, J.A., Bravo, M. (2012) Environmental assessment in a shallow subtidal rocky habitat: Approach coupling chemical and ecological tools. Chemistry and Ecology 28, 1-15 (WoS - IF: 1.3).

Sáez, C.A., Lobos, M.G., Macaya, E., Oliva, D., Quiroz, W., Brown, M.T. (2012) Variation in patterns of metal accumulation in thallus parts of Lessonia trabeculata (Laminariales; Phaeophyceae): implications for biomonitoring. PLoS ONE 7, e50170 (WoS - IF: 3.1).

* Co-first authorship

Sáez, C.A. Biología del estrés en algas y su potencial uso como herramientas de biotecnología ambiental para la detección y seguimiento de contaminación por metales. Revista Versión Diferente (2015) 1: 56-57.

Sáez, C.A. Cover picture for the journal Chemistry & Ecology, issue 1, volume 28 (2012): 

4.- Research Projects

- 2017: "Environmental monitoring of the Toltén River, Chile, after the railway collapse of August 2016". Public funded project. Role: Principal Investigator. Co-investigators: Dr. Paula Celis-Plá (LACER-UPLA); Dr. Julio Salcedo-Castro (LACER-UPLA).

- 2017-2020: “Biochemical and molecular responses disclose mechanisms of Antarctic macroalgae to thrive under Climate Change”. INACH Regular Nro. RT_09_16. Role: Principal Investigator. Co-investigators: Dr. Paula Celis Plá (LACER-UPLA); Dr. Alejandra Moenne (USACH); Dr. Francisco Cubillos (USACH); Dr. Iván Gómez (UACH); Dr. Pirjo Houvinen (UACH); Dr. Neslo Navarro (UMAG); Dr. Murray T. Brown (Plymouth University, United Kingdom).

- 2016-2019: “Transcriptome analyses reveal the basis of signal transduction involved in copper tolerance in the marine alga Ulva compressa (Chlorophyta) using Next Generation Sequencing Technologies”. FONDECYT Nro. 11160369. Role: Principal Investigator.

- 2016-2020: "Copper-induced expression of metallothioneins and synthesis of phytochelatins are involved in copper accumulation and tolerance in the marine macroalga Ulva compressa (Chlorophyta)". FONDECYT Regular Nro. 1160013. Role: Co-Investigator; Principal Invesigator Dr. Alejandra Moenne.

- 2016-2017: “Ecological and social effects of pollution caused by illegal dumping sites in Playa Ancha, Valparaíso, Chile”. Convenio Desempeño UPA 1301. Role: Principal Investigator.

- 2012-2013: “Field transplantation experiments with Ectocarpus siliculosus in central Chile”. Santander Postgraduate Internationalisation Scholarship. Role: Principal Investigator.

- 2011-2013: “Physiological, biochemical, and molecular responses to copper stress in different strains of the model brown alga Ectocarpus siliculosus”CONICYT Becas Chile Doctorado Nro. 72110557. Role: Principal Investigator.

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